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The only well-documented cases of antibiotics interfering with hormonal contraceptives that I'm aware of is the antibiotic drug Rifampicin. So yes, it is possible (if unlikely, since Rifampicin isn't used much). Nonetheless, the advice to inquire a physician is ever goodness advice, fifty-fifty to hypotheticals because if you're ever inwards that place, we don't want you relying on us, random Cyberspace people, over asking your medico (or improve yet, pharmacist with up-to-date access to journals inadditionto drug manuals.

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